US EPA

1379374 

Technical Report 

Toxicology studies on lewisite and sulfur mustard agents: Two-generation reproduction study of sulfur mustard (HD) in rats: Final report 

Sasser, LB; Miller, RA; Kalkwarf, DR; Buschbom, RL; Cushing, JA 

1989 

U.S. Army Medical Research and Development Command 

Frederick, MD 

PNL-6944 

NTIS 

NTIS/AD-A216 423 

46 pp 

English 

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Comprehensive data are not available to evaluate the potential reproductive risk from longterm exposure to sulfur mustard (HD), (bis(2-chloroethyl)sulfide). Groups of rats (27 females and 20 males/group/generation) were gavaged with 0, 0.03, 0.1 or 0.4 mg/kg HD for 13 weeks prior to mating, and throughout gestation, parturition and lactation in a 42-week two-generation study. Growth of adult F1 rats of both sexes was reduced by the 0.4 mg/kg exposure. There were no significant effects on reproductive function or pregnancy outcome in either generation. Although not different at birth, growth of the 0.4 mg/kg F1 and F2 offspring was depressed during lactation. A dose-related lesion of the squamous epithelial mucosa of the forestomach was observed in both sexes. The lesion was characterized by thickening of the squamous mucosa with varying degrees of hyperkeratosis. Benign neoplasms of the forestomach were found in about 10% of the intermediate (8/94) and high (10/94) dose groups. The NOEL for toxicity in this study was less than 0.03 mg/kg and for reproductive effects was greater than 0.4 mg/kg. 

ADA216423