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1445328 
Journal Article 
Dinuclear copper(II) complexes: Solvent dependent catecholase activity 
Banu, KS; Mukherjee, M; Guha, A; Bhattacharya, S; Zangrando, E; Das, D 
2012 
Polyhedron
ISSN: 02775387 
45 
245-254 
Four new dicopper(II) complexes of phenol based
compartmental ligands, namely [Cu-2((LH)-H-1)(2)(H2O)(2)(NO3)(2)] (NO3)(2) (1), [Cu-2(L-2)(OH)
(H2O)(NO3)](NO3) (2), [Cu-2(L-3)(2)(H2O)(NO3)](NO3) (3) and [Cu-2(L-4)(H2O)(2)(NO3)] (NO3)(2) (4)
[where L-1 = 2-formyl-4-methyl-6-(4-(aminomethyl)-piperidine)iminomethyl-phenolato, L-2 = 2,6-
bis(2-amino-2-methyl-1-propanol)iminomethyl-4-methyl-phenolato, L-3 = 2-formy1-4-methyl-6-
(benzylamine)iminomethyl-phenolato and L4 = 2,6-bis(2-aminoethylpyridine)iminomethyl-4-methyl-
phenolato] have been synthesized and structurally characterized. The single crystal X-ray
analyses reveal that all four complexes are dinuclear in nature; complexes 2 and 4 comprise of
one respective ligand, whereas 1 and 3 are contain two respective ligands, and the Cu-Cu
separation in each case is ca. 3.0 angstrom. All four complexes are soluble in dichloromethane
(DCM), methanol, acetonitrile (ACN), dimethylsulfoxide (DMSO), water-methanol (50:50, v/v), and
this property has been exploited to access the solvent effect on the catecholase activity of the
complexes towards the aerobic oxidation of 3,5-DTBC to 3,5-DTBQ. A UV-Vis spectral study in the
different solvents, followed by a kinetic investigation, suggests that the change in spectral
behavior follows a similar trend, being dependent on the coordinating ability of the solvent,
irrespective of the complex used. The commonly known physical parameters of the solvents, like
the dielectric constant, dipole moment, polarity, etc., do not seem to be a key factor in
controlling the catecholase activity. However, protic solvents are observed to be a better choice
than aprotic solvents for the oxidation of 3,5-DTBC. (C) 2012 Elsevier Ltd. All rights reserved. 
Dinuclear Cu(II); Schiff-base; Catecholase activity; Solvent effect 
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