Health & Environmental Research Online (HERO)


Print Feedback Export to File
1446643 
Journal Article 
Simultaneous Determination of Paracetamol, Phenylephrine Hydrochloride and Loratadine 
Dubey, N; Siddiqui, R; Jain, DK 
2012 
Yes 
Asian Journal of Chemistry
ISSN: 0970-7077
EISSN: 0975-427X 
24 
11 
5409-5410 
WOS:000310771100146 
A simple, selective, accurate RP-HPLC method was developed and validated for the analysis of paracetamol, phenylephrine hydrochloride and loratadine. in commercially available tablet formulations. Chromatographic separation achieved isocratically using methanol:acetonitrile: water: THF (50:40:10:2.5 % v/v/v/v) as mobile phase at a flow rate of 0.8 mL/min. The retention time of phenylephrine, paracetamol and loratadine wire found to be 2.563, 3.643, 5.779 min. respectively. The developed method was validated in terms of accuracy, precision, linearity, limit of detection, limit of quantitation. It may be used for the estimation of these drugs in combined tablet dosage forms. 
Paracetamol; Phenylephrine hydrochloride; Loratadine; RP-HPLC; Validation 
IRIS
• Methanol (Non-Cancer)
     Search Jan 30 2013
          WOS