Simultaneous Determination of Paracetamol, Domperidone and Flunarizine in Combined Tablet Dosage Form Using RP-HPLC Method | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

1446644

Reference Type

Journal Article

Title

Simultaneous Determination of Paracetamol, Domperidone and Flunarizine in Combined Tablet Dosage Form Using RP-HPLC Method

Author(s)

Dubey, N; Khan, N; Jain, DK

Year

2012

Is Peer Reviewed?

Yes

Journal

Asian Journal of Chemistry
ISSN: 0970-7077
EISSN: 0975-427X

Volume

Issue

Page Numbers

4665-4667

Web of Science Id

WOS:000310771000101

Abstract

A simple, selective, accurate high performance liquid chromatographic (HPLC) method have been developed and validated for the analysis of paracetamol, domperidone and flunarizine. Chromatographic separation was achieved on Luna C-8 column using mobile phase of methanol:acetonitrile:phosphate buffer (55:30:15, % v/v/v, pH 7.0) at a flow rate of 1.0 mL/min with UV detection at lambda(max) 249, 284 and 254 nm for paracetamol, domperidone and flunarizine, respectively. The retention time of paracetamol, domperidone and flunarizine was found to be 2.95, 4.05 and 10.3 min, respectively. The method was validated as per ICH guidelines. The method may be applied for the routine simultaneous estimation of the above mentioned drugs in tablet dosage form.

Keywords

RP-HPLC; Paracetamol; Domperidone; Flunarizine