US EPA

1449681 

Journal Article 

Solubility of Vitamin D-3 in Six Organic Solvents at Temperatures from (248.2 to 273.2) K 

Liang, R; Bao, Z; Su, B; Xing, H; Ren, Q 

2012 

Yes 

Journal of Chemical and Engineering Data
ISSN: 0021-9568
EISSN: 1520-5134 

57 

8 

2328-2331 

10.1021/je300401c 

WOS:000307264200037 

The solubility of Vitamin D-3 in methanol, ethanenitrile,
ethyl ethanoate, ethanol, propan-2-one, and propan-1-ol was measured in the temperature range
from (248.2 to 273.2) K by the static equilibrium method. The results revealed that the
solubility of Vitamin D3 in solvents was observed to decrease in the order of propan-1-ol >
ethanol > ethyl ethanoate > propan-2-one > methanol > ethanenitrile. The minimum mole fraction
solubility of 7.61.10(-5) was obtained in ethanenitrile at 248.2 K, while the maximum mole
fraction solubility up to 0.193 was obtained in propan-1-ol at 273.2 K. Moreover, the solubility
data were correlated with the simplified thermodynamic equation and the modified Apelblat
equation, and the calculated solubility for all solvents above was in good agreement with the
experimental data in the temperature range of interest.