US EPA

1449958 

Journal Article 

Bio-compatible eutectic mixture for multi-component synthesis: A valuable acidic catalyst for synthesis of novel 2,3-dihydroquinazolin-4(1H)-one derivatives 

Lobo, HR; Singh, BS; Shankarling, GS 

2012 

Yes 

Catalysis Communications
ISSN: 1566-7367 

27 

179-183 

10.1016/j.catcom.2012.07.020 

WOS:000309382100039 

Novel derivatives of quinazolin-4(1H)-one derivatives were
effectively synthesized via one-pot multi-component reaction of isatoic anhydride, aldehyde and
aromatic amines using acidic catalyst in methanol. The catalyst, being a deep eutectic mixture of
choline chloride and malonic acid, gave better results than several reported catalysts. Moreover,
such eutectic mixtures are cost-effective, recyclable, non-toxic and bio-degradable. The
methodology was successfully used for incorporating significant phenyl and heterocyclic
substitutions at 2,3-positions of quinazolinone core. In addition, studies related to catalyst
screening, substrate variation, recyclability and plausible mechanism of reaction are also
described. (C) 2012 Elsevier B.V. All rights reserved. 

Quinazolinone; Multi-component reaction; Deep eutectic solvent; Choline chloride; Malonic acid