US EPA

1450778 

Journal Article 

In vitro Antimicrobial activity of Acacia nilotica, Ziziphus mauritiana, Bauhinia variegate and Lantana camara against some clinical isolated strains 

Nagumanthri, V; Rahiman, S; Tantry, BA; Nissankararao, P; Kumar, MP 

2012 

Yes 

Iranian Journal of Science and Technology. Transaction A: Science
ISSN: 1028-6276 

36 

A2 

213-217 

WOS:000312480600010 

Plants are potent biochemists; biologically active
compounds present in the medicinal plants have always been of great interest to scientists
working in this field. Thus, the aim of the current study was to screen the antimicrobial
activity of Acacia nilotica, Ziziphus mauritiana, Bauhinia variegate and Lantana camara against
some selected clinical isolated strains. Although previous studies have documented the
antimicrobial properties of these plants, this work is designed to evaluate the specific
antibacterial activity of different extracts of these plants against tested microorganisms, in
order to know the best extract against specific microorganisms. In this study the fresh parts
(leaves, barks & pods) of the test medicinal plant were collected and methanol, ethanol and ethyl
acetate extracts were prepared. Antibacterial susceptibility test was done by using Agar
diffusion assay method. Statistical analysis was carried out with SPSS 17.0 Windows version. The
results of the current study showed that a total of 8 extracts from 4 different plant species
were investigated including pods of ethyl acetate extracts of Lantana camara, which showed the
highest antimicrobial activity against tested clinical isolates (Bacillus subtilus 2 +/- 0.1 mm,
Bacillus circulans 2.6 +/- 0.2mm, Bacillus sphaericius 2 +/- 0.1mm, Staphylococcus aureus 2.5 +/-
0.1, and Serratia liquefaciens 2.2 +/- 0.1mm), followed by its ethyl acetate extracts of leaves.
Bark extracts of four tested medicinal plants possess a lower zone on inhibitory activity as
compared to the leaves extracts of these plants. Noticeably no antimicrobial activity was found
in the methonolic bark extract of Acacia nilotica against the tested bacteria except Bacillu
ciurlans. The results of the present investigation clearly indicate that the antibacterial
activity varies with the species of the plants and plant material used. Thus, the study
ascertains the value of plants used in ayurveda, which could be of considerable interest to the
development of new drugs. Studies are in progress to further evaluate the mechanisms of action of
these active test extracts on study organisms associated with certain human diseases. 

Antimicrobial susceptibility; medicinal plants; Agar diffusion; clinical isolates