US EPA

1453202 

Journal Article 

Synthesis of Glycine Using Two-Step Reaction Approach in Alcohol and its Purification 

Yang, L; Jiang, N; Zhao, Z 

2012 

Yes 

Advanced Materials Research
ISSN: 1022-6680 

Advanced Materials Research 

396-398 

1711-1715 

10.4028/www.scientific.net/AMR.396-398.1711 

WOS:000308830101004 

A two-step reaction approach in alcohol, which comprised a step of monochoroacetic acid reacting with ammonia and a step of the resulted ammonium monochloroacetate reacting with ammonia in presence of urotropine as catalyst, was employed to synthesize glycine. Operating conditions for synthesizing glycine and for purifying glycine product were investigated through intensive experimental approach. The optimal operating conditions for the whole process including synthesis and purification of glycine were obtained and tested. Under such conditions, for methanol as reaction media and for methanol aqueous solution as separating agent, the glycine product yield reaches 92.9% with a purity of 99.7%, whereas for methanol as reaction media and for ethanol aqueous solution as separating agent, the glycine product yield is 89.5% with a purity of 98.6%. 

glycine; monochloroacetic acid; two-step reaction approach; amination method; purification