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HERO ID
1462794
Reference Type
Journal Article
Title
Comparison between Odor Thresholds for Phenyl Ethyl Alcohol and Butanol
Author(s)
Croy, I; Lange, K; Krone, F; Negoias, S; Seo, HanS; Hummel, T
Year
2009
Is Peer Reviewed?
Yes
Journal
Chemical Senses
ISSN:
0379-864X
EISSN:
1464-3553
Volume
34
Issue
6
Page Numbers
523-527
Language
English
PMID
19525318
DOI
10.1093/chemse/bjp029
Web of Science Id
WOS:000266955500008
Abstract
UNLABELLED:
Aim of the study was to compare results of odor threshold test using different numbers of dilution steps, separately for butanol and phenyl ethyl alcohol (PEA).
METHODS:
A total of 116 subjects participated (29 patients with olfactory dysfunction and 87 normosmic subjects). The olfactory threshold for butanol and PEA was examined with 8 (wide step method) and 16 (narrow step method) dilutions. With a delay of about 1 week, all 4 tests were repeated.
RESULTS:
Test time was shortened by approximately 2 min (25%) for patients when using the wide step method. Butanol and PEA thresholds were not significantly different; in addition, a significant correlation was found between thresholds for the 2 odors (r = 0.60, P < 0.001). Threshold test with both odorants as well as with wide or narrow step method provided satisfying reproducibility (test-retest reliability: r = 0.80-0.84, P < 0.001). Patients with olfactory dysfunction could be clearly separated from normosmic subjects using all 4 different tests.
DISCUSSION:
The results indicate that threshold testing with PEA is an alternative to butanol. The wide step method provided similar results as the narrow step method but required less time.
Keywords
olfactory testing; psychophysics; smell
Tags
IRIS
•
n-Butanol
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