Ahn, JH; Kim, SJ; Park, WS; Cho, SY; Ha, JD; Kim, SS; Kang, SK; Jeong, DG; Jung, SK; Lee, SH; Kim, HM; Park, SK; Lee, KH; Lee, CW; Ryu, SE; Choi, JK
A series of rhodanine derivatives was synthesized and evaluated for their ability to inhibit PRL-3. Benzylidene rhodanine derivative showed good biological activity, while compound 5e was the most active in this series exhibiting an IC50 value of 0.9 microM in vitro and showed a reduced invasion in cell-based assay.