US EPA

1469967 

Journal Article 

Structure-activity relationships of the diuretic activity of triaza- and tetraaza-naphthalene compounds 

Nishikawa, K; Shimakawa, H; Inada, Y; Shibouta, Y; Kikuchi, S 

1976 

Yes 

Chemical and Pharmaceutical Bulletin
ISSN: 0009-2363
EISSN: 1347-5223 

24 

9 

2057-2077 

English 

991360 

10.1248/cpb.24.2057 

WOS:A1976CG21700015 

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0017094095&doi=10.1248%2fcpb.24.2057&partnerID=40&md5=acb761c24ee1bd1dd9322e8edb114286
Exit
 

The diuretic activity of 219 nitrogen containing heterocyclic compounds, classified into 13 groups based on the structural features, was studied on the saline loaded rats. One hundred and four out of the 219 compounds were active at the oral doses of 10 to 30 mg/kg. Several of pyrimidopyridazines, pyridazinopyridazines and pyridopyridazines produced as potent diuresis and natriuresis as hydrochlorothiazide at the oral dose of 0.1 mg/kg, in which 2-phenyl-5,8-dimorpholinopyrimido[4,5-d]-pyridazine (DS-210) and l,4-dimorpholino-7-phenylpyrido[3,4-d]pyridazine (DS-511) were selected for more extensive evaluation as diuretic agents. Structure-activity relationships of the tested compounds are discussed. © 1976, The Pharmaceutical Society of Japan. All rights reserved.