US EPA

1489469 

Journal Article 

Effects of feeding aspirin and supplemental vitamin E on plasma concentrations of 3-methylindole, 3-methyleneindolenine-adduct concentrations in blood and pulmonary tissues, lung lesions, and growth performance in feedlot cattle 

Loneragan, GH; Morley, PS; Wagner, JJ; Mason, GL; Yost, GS; Thoren, MA; Wittum, TE; Bray, TM 

2002 

Yes 

American Journal of Veterinary Research
ISSN: 0002-9645
EISSN: 1943-5681 

63 

12 

1641-1647 

12492277 

10.2460/ajvr.2002.63.1641 

WOS:000179676100005 

http://://WOS:000179676100005
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Objective-To evaluate the effect of feeding aspirin and
supplemental vitamin E on growth performance, lung lesions, plasma concentrations of 3-
methylindole (3MI), and 3-methyleneindolenine (3MEIN)-adduct concentrations in blood and
pulmonary tissues of feedlot cattle. Animals-256 crossbred steers; 64 cattle were used in
experiment 1 and 192 cattle were used in experiment 2. Procedures-A 2 X 2 factorial design was
used for each experiment. Treatment factors were aspirin (0 or 3 g daily) and vitamin E (200 or
1,500 IU daily). Steers were housed in pens (8 steers/pen). Steers were slaughtered on days 59
and 138 for experiments 1 and 2, respectively. Lungs were grossly evaluated. Plasma 3MI
concentration was determined, and 3MEIN-adduct concentrations were measured in blood and
pulmonary tissues. Results-Treatment was not associated with improvement or adverse effects on
weight gain, dry-matter intake, or feed efficiency in experiment 2. In experiment 1, 36 of 63
(57.1%) steers had lung lesions. Lesions were not associated with treatment or concentrations of
3MI and 3MEIN-adduct. Plasma 3MI concentration and concentrations of 3MEIN-adduct in blood and
pulmonary tissues were 3.11 mug/mL, 0.51 U/mug of protein, and 0.49 U/mug of protein,
respectively. Aspirin was associated with increased blood concentrations of 3MEIN-adduct for
diets that did not contain supplemental vitamin E. Conclusions and Clinical Relevance-Differences
in performance of feedlot steers were not associated with treatment diet. It is possible that
concurrent exposure of feedlot cattle to other factors typically associated with development of
respiratory tract disease would affect these findings.