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Citation
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HERO ID
1599720
Reference Type
Technical Report
Title
Cyclic acid anhydrides: Human health aspects
Author(s)
Kim, JH; Gibb, HJ; Iannucci, A; Inter-Organization Programme for the Sound Management of Chemicals (IOMC)
Year
2009
Report Number
CIS/09/00895
Volume
Distribution and Sales Service
Language
eng
Abstract
This criteria document covers 14 dicarboxylic acid anhydrides widely used in the chemical industry. In humans, cyclic acid anhydrides can cause irritation and sensitization after direct contact with the skin and the mucous membranes or after exposure by inhalation. Irritation is caused by the corresponding dicarboxylic acid that is formed when cyclic acid anhydrides interact with water. The most common allergic diseases are rhinoconjunctivitis and asthma. Acute toxicity in animals is low, all the more so for the most widespread products, namely phthalic and maleic anhydride. There are few long-term exposure or carcinogenicity studies. Ames tests and chromosomal aberration assays did not reveal any mutagenicity or genotoxicity. Summaries in French and Spanish are included.
Keywords
carboxylic acid anhydrides
;
dicarboxylic acids
;
IPCS
;
toxicology
;
allergens
;
allergic asthma
;
animal experiments
;
conjunctivitis
;
criteria document
;
ecotoxicology
;
ILO
;
inhalation toxicity
;
irritants
;
lethal dose 50
;
literature survey
;
maleic acid hydrazide
;
phthalic anhydride
;
rhinitis
;
routes of entry
;
sensitizers
;
toxic effects
;
UNEP
;
WHO
;
Toxic and dangerous substances
;
Chemical safety
;
Books, reports, proceedings
Tags
IRIS
•
Phthalates – Targeted Search for Epidemiological Studies
Source – all searches
Toxnet
Excluded
Source – no date limit through June 2013 (Private)
ToxNet
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