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1599720 
Technical Report 
Cyclic acid anhydrides: Human health aspects 
Kim, JH; Gibb, HJ; Iannucci, A; Inter-Organization Programme for the Sound Management of Chemicals (IOMC) 
2009 
CIS/09/00895 
Distribution and Sales Service 
eng 
This criteria document covers 14 dicarboxylic acid anhydrides widely used in the chemical industry. In humans, cyclic acid anhydrides can cause irritation and sensitization after direct contact with the skin and the mucous membranes or after exposure by inhalation. Irritation is caused by the corresponding dicarboxylic acid that is formed when cyclic acid anhydrides interact with water. The most common allergic diseases are rhinoconjunctivitis and asthma. Acute toxicity in animals is low, all the more so for the most widespread products, namely phthalic and maleic anhydride. There are few long-term exposure or carcinogenicity studies. Ames tests and chromosomal aberration assays did not reveal any mutagenicity or genotoxicity. Summaries in French and Spanish are included. 
carboxylic acid anhydrides; dicarboxylic acids; IPCS; toxicology; allergens; allergic asthma; animal experiments; conjunctivitis; criteria document; ecotoxicology; ILO; inhalation toxicity; irritants; lethal dose 50; literature survey; maleic acid hydrazide; phthalic anhydride; rhinitis; routes of entry; sensitizers; toxic effects; UNEP; WHO; Toxic and dangerous substances; Chemical safety; Books, reports, proceedings