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1619655 
Journal Article 
Safety evaluation of cosmetic raw materials 
Guillot, JP; Martini, MC; Giauffret, JY 
1977 
0 
Journal of the Society of Cosmetic Chemists
ISSN: 0037-9832 
28 
377-393 
English 
IPA COPYRIGHT: ASHP The toxicity of 26 cosmetics excipients was evaluated using a rabbit test. The ocular and cutaneous effects were evaluated using official French methods with some additions. The results show that 13 samples gave adverse reactions after repeated skin exposures; 8 of them appeared to be significantly more irritant--4 isopropyl myristates and 4 oleyl alcohols each from different sources. Eleven excipients were well tolerated when applied undiluted during 60 days and 2 gave uncertain results. Compounds tested included squalane, caprylic triglycerides, isopropyl myristate and palmitate, decyl oleate, octyl palmitate and stearate, oleyl alcohol and polyoxyethylene sorbitan stearate. 
Excipients; cosmetics; toxicity; Toxicity; excipients; Squalane; cutaneous; Caprylic triglycerides; Isopropyl myristate; Isopropyl palmitate; Octyl palmitate; Octyl stearate; Alcohols; Polyoxyethylene sorbitan stearate; Methodology; cosmetics 
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