US EPA

184386 

Journal Article 

Risk factors in renal cell carcinoma. II. Medical history, occupation, multivariate analysis, and conclusions 

Asal, NR; Geyer, JR; Risser, DR; Lee, ET; Kadamani, S; Cherng, N 

1988 

Yes 

Cancer Detection and Prevention
ISSN: 0361-090X
EISSN: 1525-1500 

13 

3-4 

263-279 

English 

3266567 

Potential risk factors in renal cell carcinoma (RCC) were studied in a case-control study of 315 RCC cases and 313 hospital and 336 population controls. Risk factors included medical history, radiation exposure, predominant lifetime occupation, exposure to high-risk industries, and summary of important risk factors by a linear logistic regression model based on the comparison of RCC cases and controls selected from hospitals and the general population for 33 variables. A significant increase in urologic, cardiovascular, malignant, digestive, and metabolic disease was observed among cases over population controls. Exposure to radiation increased the risk, especially in females. A predominant lifetime occupation as a professional decreased the risk, whereas work as an operative increased the risk significantly. Work in petroleum-related and dry-cleaning industries were associated with elevated risk. Multivariate analysis comparing cases with each of the control groups for males and females identified obesity as the most important risk factor in RCC. Weight control at an early age might help to prevent the occurrence of a significant proportion of this rare but increasing malignant disease.