Methanol intoxication-induced nigrostriatal dysfunction detected using 6-[18F]fluoro-L-dopa PET | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

196177

Reference Type

Journal Article

Title

Methanol intoxication-induced nigrostriatal dysfunction detected using 6-[18F]fluoro-L-dopa PET

Author(s)

Airas, L; Paavilainen, T; Marttila, RJ; Rinne, J

Year

2008

Is Peer Reviewed?

Journal

NeuroToxicology
ISSN: 0161-813X
EISSN: 1872-9711

Volume

Issue

Page Numbers

671-674

Language

English

PMID

18482768

DOI

10.1016/j.neuro.2008.03.010

Abstract

Ingestion of windshield washer liquid resulted with an acute severe methanol intoxication in a 49-year old man. He developed optic atrophy with blindness, and an extrapyramidal syndrome. Putaminal injury and hyperintensity in the subcortical white matter was seen in a brain MRI. PET scanning with 6-[18F]fluoro-l-dopa confirmed symmetrical impaired presynaptic dopaminergic activity in the striatum, indicative of functional impairment of dopaminergic nigrostriatal neurons. The striatal uptake was more markedly impaired in the putamina (40% of controls) than in the caudate nuclei (60% of controls). To our knowledge, this is the first report of an 18F-dopa PET scanning result in a case of an acute methanol poisoning.