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196803 
Journal Article 
Altered behaviour in adult mice orally exposed to tri- and tetrachloroethylene as neonates 
Fredriksson, A; Danielsson, BRG; Eriksson, P 
1993 
1 
Toxicology Letters
ISSN: 0378-4274
EISSN: 1879-3169 
NIOSH/00212863 
Toxicology Letters 
66 
1 
13-19 
English 
8427017 
Male NMRI mice were orally exposed to trichloethylene (TRI, 50 and 290 mg/kg per day) and tetrachloroethylene (PER, 5 and 320 mg/kg per day) between days 10 and 16 postnatally. Spontaneous activity, observed as locomotion, rearing and total activity, was measured over three 20-mm periods at an age of 17 and 60 days. Compared to controls, mice at 17 days of age were unaffected, while at 60 days of age mire exposed to PER showed changes in all three spontaneous motor activity variables, while TRI-exposeds mice only were affected in rearing 
Behaviour; Solvents; Trichloroethylene; Tetrachloroethylene; Neonatal; Adult 
• Tetrachloroethylene (Perc) (Final, 2012)
     Hazard
          Neuro
          Repro/Dev
          Susceptibility
• Trichloroethylene (TCE) (Final, 2011)
     All References
     Hazard
     Neuro
     Repro/Dev
     Susceptibility
     Dose-Response
     Non-Cancer
OPPT REs
• OPPT_N-methylpyrrolidone (NMP)_F. Human Health
     Total – title/abstract screening
          On topic
               Peer review
                    Primary source
• OPPT_Perchloroethylene (Perc)_A. Summary
     Cited in TSCA RE related document
• OPPT_Perchloroethylene (Perc)_F. Human Health
     Total – title/abstract screening
          On topic
               Peer review
                    Primary source
               Cited in IRIS document or IRIS HERO page
     On topic - additional tags for titles/abstracts
          Animal hazard ID
• OPPT_Trichloroethylene (TCE)_F. Human Health
     Total – title/abstract screening
          On topic
               Peer review
                    Primary source
               Cited in IRIS document or IRIS HERO page
     On topic - additional tags for titles/abstracts
          Animal hazard ID