US EPA

1997743 

Journal Article 

Letter 

Aluminum contamination of dialysis and intravenous fluids after asbestos-free depth filtration 

Vyth, A; Stolk, LM; Abbad, FC 

1986 

Yes 

American Journal of Hospital Pharmacy
ISSN: 0002-9289 

IPA/87/716018 

43 

10 

2390 

English 

3788988 

WOS:A1986E449100006 

IPA COPYRIGHT: ASHP The case of a pediatric continuous ambulatory peritoneal dialysis (CAPD) patient who developed high blood levels of aluminum (I) was briefly reported. It was found that dialysis fluid prepared by the hospital contained high concentration of I. Tests were conducted of the filters used to prepare the dialysis fluids and intravenous solutions. When CAPD solution was filtered through filters rinsed with sterile water, the concentrations of I in the solution after 40, 90, and 140 liters were filtered were 1140, 1110, and 700 mcg/l, respectively. Before filtration, the concentration of I in this solution was only 3 mcg/l. In other batches of CAPD solution, I concentrations of up to 7000 mcg/l were found. Some intravenous fluids prepared for patients in the neonatal ward also contained high concentrations of I, especially those fluids that also contained calcium gluconate. It was concluded that the factors that may contribute to increased washout of I from the filter material include high pH and osmolarity of the IV fluid, presence of divalent cations in the fluid, and a relatively slow filtration rate (in the case of small batches). 

Asbestos; 1332-21-4; Aluminum; CPD4NFA903; Index Medicus; Filtration; Dialysis; Infusions, Intravenous; Aluminum -- analysis; Drug Contamination