Butyrylated starch increases colonic butyrate concentration but has limited effects on immunity in healthy physically active individuals | Health & Environmental Research Online (HERO)

Health & Environmental Research Online (HERO)

Print Feedback Export to File

This record has one attached file:

Citation
Tags

HERO ID

2279974

Reference Type

Journal Article

Title

Butyrylated starch increases colonic butyrate concentration but has limited effects on immunity in healthy physically active individuals

Author(s)

West, NP; Christophersen, CT; Pyne, DB; Cripps, AW; Conlon, MA; Topping, DL; Kang, S; Mcsweeney, CS; Fricker, PA; Aguirre, D; Clarke, JM

Year

2013

Is Peer Reviewed?

Yes

Journal

Exercise Immunology Review
ISSN: 1077-5552

Volume

Page Numbers

102-119

Language

English

PMID

23977723

Web of Science Id

WOS:000323184600008

Abstract

BACKGROUND: Butyrate delivery to the large bowel may positively modulate commensal microbiota and enhance immunity.

OBJECTIVE: To determine the effects of increasing large bowel butyrate concentration through ingestion of butyrylated high amylose maize starch (HAMSB) on faecal biochemistry and microbiota, and markers of immunity in healthy active individuals.

DESIGN: Male and female volunteers were assigned randomly to consume either two doses of 20 g HAMSB (n = 23; age 37.9 +/- 7.8 y; mean +/- SD) or a low amylose maize starch (LAMS) (n = 18; age 36.9 = 9.5 y) twice daily for 28 days. Samples were collected on days 0, 10 and 28 for assessment of faecal bacterial groups, faecal biochemistry, serum cytokines and salivary antimicrobial proteins.

RESULTS: HAMSB led to relative increases in faecal free (45%; 12-86%; mean; 90% confidence interval; P = 0.02), bound (950%; 563-1564%; P < 0.01) and total butyrate (260%; 174-373%; P < 0.01) and faecal propionate (41%; 12-77%; P = 0.02) from day 0 to day 28 compared to LAMS. HAMSB was also associated with a relative 1.6-fold (1.2- to 2.0-fold; P < 0.01) and 2.5-fold (1.4- to 4.4-fold; P = 0.01) increase in plasma IL-10 and TNF-alpha but did not alter other indices of immunity. There were relative greater increases in faecal P. distasonis (81-fold (28- to 237-fold; P < 0.01) and F. prausnitzii (5.1-fold (2.1- to 12-fold; P < 0.01) in the HAMSB group.

CONCLUSIONS: HAMSB supplementation in healthy active individuals promotes the growth of bacteria that may improve bowel health and has only limited effects on plasma cytokines.

Keywords

Butyrylated starch; immunity; exercise; short chain fatty acids; faecal microbiota