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2328033 
Journal Article 
Review 
Genome-wide association studies for common diseases and complex traits 
Hirschhorn, JN; Daly, MJ 
2005 
1 
Nature Reviews. Genetics
ISSN: 1471-0056
EISSN: 1471-0064 
6 
2 
95-108 
English 
15716906 
Genetic factors strongly affect susceptibility to common diseases and also influence disease-related quantitative traits. Identifying the relevant genes has been difficult, in part because each causal gene only makes a small contribution to overall heritability. Genetic association studies offer a potentially powerful approach for mapping causal genes with modest effects, but are limited because only a small number of genes can be studied at a time. Genome-wide association studies will soon become possible, and could open new frontiers in our understanding and treatment of disease. However, the execution and analysis of such studies will require great care.