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Citation
Tags
HERO ID
2333423
Reference Type
Journal Article
Title
Inflammatory response to fine particulate air pollution exposure: Neutrophil versus monocyte
Author(s)
Xu, X; Jiang, SY; Wang, T; Bai, Y; Zhong, M; Wang, A; Lippmann, M; Chen, L; Rajagopalan, S; Sun, Q
Year
2013
Is Peer Reviewed?
1
Journal
PLoS ONE
EISSN:
1932-6203
Volume
8
Issue
8
Page Numbers
e71414
Language
English
PMID
23951156
DOI
10.1371/journal.pone.0071414
Web of Science Id
WOS:000323124000056
Abstract
OBJECTIVES:
Studies have shown that chronic exposure to ambient fine particulate matter (less than 2.5 µm in aerodynamic diameter, PM₂.₅) pollution induces insulin resistance through alterations in inflammatory pathways. It is critical to study how the immune system responds to this stimulant, which has been linked to cardiovascular and autoimmune diseases, but few studies have been focused on such involvement of both neutrophils and monocytes in a timely manner. We hypothesized that the neutrophil was involved in the inflammatory response to air pollution.
METHODS AND RESULTS:
C57BL/6 mice were exposed to PM₂.₅ or filtered air (6 hours/day, 5 days/week) for 5, 14, and 21 days, respectively, in Columbus, OH. At the end of each of the exposure periods, we investigated the inflammatory response through flow cytometry, histology, intravital microscopy, and real-time PCR. PM₂.₅-exposed mice demonstrated a significant inflammatory response after 5 days of exposure. In the lung tissue and bronchoalveolar lavage fluid, monocytes/macrophages showed a transient response, while neutrophils showed a cumulative response. In addition, exposure to PM₂.₅ resulted in elevation of the monocyte chemoattractant protein 1 (MCP-1) cytokine, a monocyte/macrophage attractant in blood, at an early stage of exposure.
CONCLUSIONS:
These findings suggest that PM₂.₅ exposure induces the inflammatory responses from both macrophages and neutrophils involvement.
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ISA-PM (2019)
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