US EPA

2349666 

Journal Article 

Gasotransmitters: growing pains and joys 

Wang, R 

2014 

1 

Trends in Biochemical Sciences
ISSN: 0968-0004 

39 

5 

227-232 

English 

24767680 

10.1016/j.tibs.2014.03.003 

WOS:000336360100003 

http://www.sciencedirect.com/science/article/pii/S0968000414000516
Exit
 

Gasotransmitters are endogenously generated molecules of gas. Over the past decade we have come to realize that these gaseous signaling molecules are crucially important, being irreplaceable in wide biological applications. However, there are still many challenges for future gasotransmitter research to tackle. These include clarifying the interactions among gasotransmitters; understanding the significance of the cellular gasotransmitter signaling network; and adding new members to the modern family of gasotransmitters in addition to nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S). Ammonia fulfills all criteria for being a gasotransmitter, and methane is another conceivable candidate. Following the original article postulating the concept of multiple gasotransmitters over a decade ago, this sequel article aims to further inspire interest and exploration into gasotransmitter research. 

gasotransmitter; nitric oxide; carbon monoxide; hydrogen sulfide; ammonia; methane