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HERO ID
2821992
Reference Type
Journal Article
Title
Locomotor activity and sensory-motor developmental alterations in rat offspring exposed to arsenic prenatally and via lactation
Author(s)
Gumilar, F; Lencinas, I; Bras, C; Giannuzzi, L; Minetti, A
Year
2015
Is Peer Reviewed?
1
Journal
Neurotoxicology and Teratology
ISSN:
0892-0362
EISSN:
1872-9738
Volume
49
Page Numbers
1-9
Language
English
PMID
25725132
DOI
10.1016/j.ntt.2015.02.005
Web of Science Id
WOS:000357142700001
Abstract
Arsenic (As) is one of the most toxic naturally occurring contaminants in the environment. The major source of human exposure to inorganic As (iAs) is through contaminated drinking water. Although both genotoxicity and carcinogenicity derived from this metalloid have been thoroughly studied, the effects of iAs on the development and function of the central nervous system (CNS) have received less attention and only a few studies have focused on neurobehavioral effects. Thus, in order to characterize developmental and behavioral alterations induced by iAs exposure, pregnant Wistar rats were exposed to 0.05 and 0.10mg/L iAs through drinking water during gestation and lactation. Sensory-motor reflexes in each pup were analyzed and the postnatal day when righting reflex, cliff aversion and negative geotaxis were observed was recorded. Functional Observational Battery (FOB) and locomotor activity in an open field were assessed in 90-day-old offspring. Results show that rats exposed to low iAs concentrations through drinking water during early development evidence a delay in the development of sensory-motor reflexes. Both FOB procedure and open-field tests showed a decrease in locomotor activity in adult rats. This study reveals that exposure to the above-mentioned iAs concentrations produces dysfunction in the CNS mechanisms whose role is to regulate motor and sensory development and locomotor activity.
Keywords
Arsenic; Development exposure; Sensory-motor reflexes; Functional Observational Battery; Locomotor activity; Rat
Tags
IRIS
•
Arsenic Hazard ID
Lit Search Updates Oct 2015 to Jan 2019
WOS
2.5 Update 2015-2019: Title & Abstract Screening
Not relevant to PECO
8. Hazard through Oct 2015
Animal Hazard ID
•
Arsenic (Inorganic)
3. Hazard ID Screening
Potentially relevant toxicology studies
Cited in Volume 1
Cited in Volume 2a
•
Arsenic Susceptibility
Life Stages Citation Mapping
10%-15%
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