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HERO ID
2993265
Reference Type
Journal Article
Title
Exposure to medium and high ambient levels of ozone causes adverse systemic inflammatory and cardiac autonomic effects
Author(s)
Arjomandi, M; Wong, H; Donde, A; Frelinger, J; Dalton, S; Ching, W; Power, K; Balmes, JR
Year
2015
Is Peer Reviewed?
Yes
Journal
American Journal of Physiology: Heart and Circulatory Physiology
ISSN:
0363-6135
EISSN:
1522-1539
Volume
308
Issue
12
Page Numbers
H1499-1509
Language
English
PMID
25862833
DOI
10.1152/ajpheart.00849.2014
Web of Science Id
WOS:000356273200005
URL
http://ajpheart.physiology.org/content/ajpheart/308/12/H1499.full.pdf
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Abstract
Epidemiological evidence suggests that exposure to ozone increases cardiovascular morbidity. However, the specific biological mechanisms mediating ozone-associated cardiovascular effects are unknown. To determine whether short-term exposure to ambient levels of ozone causes changes in biomarkers of cardiovascular disease including heart rate variability (HRV), systemic inflammation, and coagulability, 26 subjects were exposed to 0, 100, and 200 ppb ozone in random order for 4 h with intermittent exercise. HRV was measured and blood samples were obtained immediately before (0 h), immediately after (4 h), and 20 h after (24 h) each exposure. Bronchoscopy with bronchoalveolar lavage (BAL) was performed 20 h after exposure. Regression modeling was used to examine dose-response trends between the endpoints and ozone exposure. Inhalation of ozone induced dose-dependent adverse changes in the frequency domains of HRV across exposures consistent with increased sympathetic tone [increase of (parameter estimate +/- SE) 0.4 +/- 0.2 and 0.3 +/- 0.1 in low-to high-frequency domain HRV ratio per 100 ppb increase in ozone at 4 h and 24 h, respectively (P = 0.02 and P = 0.01)] and a dosedependent increase in serum C-reactive protein (CRP) across exposures at 24 h [increase of 0.61 +/- 0.24 mg/l in CRP per 100 ppb increase in ozone (P = 0.01)]. Changes in HRV and CRP did not correlate with ozone-induced local lung inflammatory responses (BAL granulocytes, IL-6, or IL-8), but changes in HRV and CRP were associated with each other after adjustment for age and ozone level. Inhalation of ozone causes adverse systemic inflammatory and cardiac autonomic effects that may contribute to the cardiovascular mortality associated with short-term exposure.
Keywords
ozone; inhalational exposure; heart rate variability; systemic inflammation; airway inflammation
Tags
•
ISA-Ozone (2013 Final Project Page)
•
ISA-Ozone (2020 Final Project Page)
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Topic Classified Epidemiology
Topic Classified Experimental
Title-Abstract Screening (SWIFT-AS) - Included
Title-Abstract Screening (SWIFT-AS) - Included
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Appendix 3
Appendix 4
Included in ISA Final Draft
Appendix 3
Appendix 4
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