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2997882 
Journal Article 
Resolution of Enantiomers of Novel C-2-Symmetric Aminobisphosphinic Acids via Diastereomeric Salt Formation With Quinine 
Kaboudin, B; Faghihi, MR; Kazemi, F; Yokomatsu, T 
2015 
Yes 
Chirality
ISSN: 0899-0042 
27 
1 
71-74 
English 
25319000 
WOS:000346790800010 
C2 -symmetric N,N-bis(phosphinomethyl)amines were prepared by the thermal reaction of aromatic aldehydes with ammonia and hypophosphorus acid as previously described. Both enantiomers of C2 -symmetric N,N-bis(phosphinomethyl)amine were obtained in a high enantiomeric purity through the diastereomeric salt formation with (-)-quinine, and subsequent fractional crystallization. X-ray crystallographic analysis of one of the diastereomeric salts clearly revealed that (-)-quinine could be an efficient resolving agent for obtaining the single enantiomer (R,R)-N,N-bis(phosphinomethyl)amine. 
C-2-symmetric; -aminophosphinic acids; thermal reaction