Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
3603249
Reference Type
Journal Article
Title
Traffic-related air pollution impact on mouse brain accelerates myelin and neuritic aging changes with specificity for CA1 neurons
Author(s)
Woodward, NC; Pakbin, P; Saffari, A; Shirmohammadi, F; Haghani, A; Sioutas, C; Cacciottolo, M; Morgan, TE; Finch, CE
Year
2017
Is Peer Reviewed?
1
Journal
Neurobiology of Aging
ISSN:
0197-4580
EISSN:
1558-1497
Publisher
Elsevier
Volume
53
Issue
Elsevier
Page Numbers
48-58
Language
English
PMID
28212893
DOI
10.1016/j.neurobiolaging.2017.01.007
Web of Science Id
WOS:000399501300006
URL
https://linkinghub.elsevier.com/retrieve/pii/S0197458017300088
Exit
Abstract
Traffic-related air pollution (TRAP) is associated with lower cognition and reduced white matter volume in older adults, specifically for particulate matter <2.5-μm diameter (PM2.5). Rodents exposed to TRAP have shown microglial activation and neuronal atrophy. We further investigated age differences of TRAP exposure, with focus on hippocampus for neuritic atrophy, white matter degeneration, and microglial activation. Young- and middle-aged mice (3 and 18 months female C57BL/6J) were exposed to nanoscale-PM (nPM, <0.2 μm diameter). Young mice showed selective changes in the hippocampal CA1 region, with neurite atrophy (-25%), decreased MBP (-50%), and increased Iba1 (+50%), with dentate gyrus relatively unaffected. Exposure to nPM of young mice decreased GluA1 protein (-40%) and increased TNFa mRNA (10×). Older controls had age changes approximating nPM effects on young, with no response to nPM, suggesting an age-ceiling effect. The CA1 selective vulnerability in young mice parallels CA1 vulnerability in Alzheimer's disease. We propose that TRAP-associated human cognitive and white matter changes involve hippocampal responses to nPM that begin at younger ages.
Tags
•
ISA-PM (2019)
1st Draft
Chapter 8
Final ISA
Chapter 8
•
LitSearch-NOx (2024)
Forward Citation Search
Epidemiology
Results
Cardiovascular-ST
PubMed
WoS
Exposure
Results
Confounding
PubMed
WoS
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity