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Journal Article 
Dietary vitamin C reduced mercury contents in the tissues of juvenile olive flounder (Paralichthys olivaceus) exposed with and without mercury 
Lee, JH; Moniruzzaman, M; Yun, H; Lee, S; Park, Y; Bai, SC 
Environmental Toxicology and Pharmacology
ISSN: 1382-6689
EISSN: 1872-7077 
A 2×3 factorial design was employed to evaluate the effects of dietary vitamin C (l-ascorblyl-2-monophosphate, C2MP) levels on growth and tissue mercury (Hg) accumulations in juvenile olive flounder, Paralichthys olivaceus. Six experimental diets with two levels of mercuric chloride (0 or 20mg HgCl2/kg diet) and three levels of vitamin C (0, 100, or 200mg C2MP/kg diet) were added to the basal diet. At the end of 6 weeks feeding trial, in presence or absence of dietary Hg, fish body weight gain, specific growth rate, feed efficiency, protein efficiency ratio and whole body lipid content were increased in a dose-dependent manner as dietary vitamin C level increased in the diets. Interestingly, fish fed 100 or 200mg C2MP/kg diets showed significant interactive effects on reducing Hg content in kidney tissue. These results revealed that dietary vitamin C as 100 or 200mg C2MP/kg diet had protective effect against Hg accumulation in juvenile olive flounder. 
Vitamin C; Mercuric chloride; Growth; Tissue mercury content; Olive flounder 
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