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HERO ID
3859962
Reference Type
Journal Article
Title
Depletion of mitochondrial CoA by perfluorosulfonic and perfluorocarboxylic acids in vitro
Author(s)
O'Brien, TM; Wallace, KB
Year
2004
Is Peer Reviewed?
1
Journal
Toxicologist
ISSN:
0731-9193
Volume
78
Issue
1 Suppl.
Page Numbers
104
Language
English
Abstract
Perfluorooctanesulfonate (PFOS), perfluorooctanoic acid (PFOA), and the substituted perfluorooctanesulfonamides perfluorooctanesulfonamidoacetate (FOSAA), and N-ethylperfluorooctanesulfonamidoacetate (N-Et-FOSAA) are widely used as surfactants on fabrics and papers, as anti-corrosion agents and fire retardants, as well as many other commercial applications. Their broad use, global distribution, and environmental persistence has generated considerable interest regarding the metabolic and potentially toxic effects of these compounds. We have previously shown that the perfluorooctanes disrupt mitochondrial bioenergetics and, more specifically, that perfluorinated carboxylic acids induce the mitochondrial permeability transition. The purpose of this study was to determine if, as structural fatty acid analogues, perfluorosulfonic acid and perfluorinated carboxylic acids deplete free coenzyme A. Freshly homogenized rat liver was incubated in the presence of the test compound at 37 C for 40 minutes. Caprylic acid was included as a positive control and the concentration of free coenzyme A determined by reversed-phase HPLC. The concentration of free CoA detected in the control incubations was 92.4 +/- 13.6 nmol/g liver. Incubation with caprylic acid caused a 5% decrease in free CoA, whereas there was a 15%-40% depletion of CoA when liver tissue was incubated with one or another of the perfluorinated acids. We conclude that PFOS and the perfluorinated carboxylic acids deplete free mitochondrial coenzyme A, and that this may contribute to the mechanism by which these compounds interfere with fatty acid metabolism in vivo
Tags
•
NEtFOSAA
Literature Search
Toxline
Screening Results
Excluded/Not on Topic
•
^Per- and Polyfluoroalkyl Substances (PFAS)
PFOSA (754-91-6)
Literature Search
Toxline
NEtFOSAA (2991-50-6)
Literature Search
Toxline
•
PFAS 150
Literature Search August 2019
ToxNet
Screened Studies
Excluded
Exclude (TIAB)
N-Ethylperfluorooctanesulfonamide
Perfluorooctanesulfonate
Perfluorooctanesulfonic acid
Perfluorooctanoic acid
•
PFOSA
Literature Search
Toxline
Screening Results
Excluded/Not on Topic
Other
•
Yale PFAS Liver study
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