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Citation
Tags
HERO ID
3860595
Reference Type
Journal Article
Title
High Resolution Mass Spectrometry of Polyfluorinated Polyether-Based Formulation
Author(s)
Dimzon, IK; Trier, X; Frömel, T; Helmus, R; Knepper, TP; de Voogt, P
Year
2016
Is Peer Reviewed?
1
Journal
Journal of the American Society for Mass Spectrometry
ISSN:
1044-0305
EISSN:
1879-1123
Publisher
SPRINGER
Location
NEW YORK
Volume
27
Issue
2
Page Numbers
309-318
Language
English
PMID
26519300
DOI
10.1007/s13361-015-1269-9
Web of Science Id
WOS:000368708000013
Abstract
High resolution mass spectrometry (HRMS) was successfully applied to elucidate the structure of a polyfluorinated polyether (PFPE)-based formulation. The mass spectrum generated from direct injection into the MS was examined by identifying the different repeating units manually and with the aid of an instrument data processor. Highly accurate mass spectral data enabled the calculation of higher-order mass defects. The different plots of MW and the nth-order mass defects (up to n = 3) could aid in assessing the structure of the different repeating units and estimating their absolute and relative number per molecule. The three major repeating units were -C2H4O-, -C2F4O-, and -CF2O-. Tandem MS was used to identify the end groups that appeared to be phosphates, as well as the possible distribution of the repeating units. Reversed-phase HPLC separated of the polymer molecules on the basis of number of nonpolar repeating units. The elucidated structure resembles the structure in the published manufacturer technical data. This analytical approach to the characterization of a PFPE-based formulation can serve as a guide in analyzing not just other PFPE-based formulations but also other fluorinated and non-fluorinated polymers. The information from MS is essential in studying the physico-chemical properties of PFPEs and can help in assessing the risks they pose to the environment and to human health. Graphical Abstract ᅟ.
Tags
PFAS
•
Additional PFAS (formerly XAgency)
Literature Search November 2019
PubMed
Web of Science
Not prioritized for screening
Perfluoropentanesulfonic acid
•
Expanded PFAS SEM (formerly PFAS 430)
Perfluoropentanesulfonate
•
^Per- and Polyfluoroalkyl Substances (PFAS)
PFPeS (2706-91-4)
Literature Search
Pubmed
WOS
•
PFPeS
Literature Search
Pubmed
WOS
Screening Results
Excluded/Not on Topic
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