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3860772 
Journal Article 
Syntheses of Biologically Active 2-Arylcyclopropylamines 
Miyamura, S; Itami, K; Yamaguchi, J 
2017 
Yes 
Synthesis
ISSN: 0039-7881 
49 
1131-1149 
The 2-arylcyclopropylamine (ACPA) motif is often seen in biologically active compounds. This review focuses on the synthesis of biologically active ACPAs and categorizes, by reaction type, the synthetic methods used toward such compounds.



1 Introduction



2 Cyclopropanation Using Diazo Compounds



2.1 Styrene



2.2 Cinnamate



2.3 Vinyl Phthalimide



2.4 Vinyl Acetamide



2.5 Oxazolone



2.6 Diketopiperazine



3 Cyclopropanation Using Ylides



3.1 Cinnamate



3.2 Nitrostyrene



3.3 Oxirane



3.4 Nitroacetate



4 Transformation of Cyclopropanes



4.1 Iodocyclopropane



4.2 Aminocyclopropane



5 Miscellaneous Methods



5.1 Kulinkovich Reaction



5.2 Three-Component Reaction



5.3 Intramolecular Nucleophilic Cyclization



5.4 Intramolecular Mitsunobu Reaction



5.5 Rearrangement from Cyclobutanone



6 Summary 
arylcyclopropylamine; cyclopropanes; biologically active compounds 
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