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Citation
Tags
HERO ID
3982695
Reference Type
Journal Article
Title
Liver metabolic disruption induced after a single exposure to PCB126 in rats
Author(s)
Chapados, NA; Boucher, MP
Year
2017
Is Peer Reviewed?
Yes
Journal
Environmental Science and Pollution Research
ISSN:
0944-1344
EISSN:
1614-7499
Volume
24
Issue
2
Page Numbers
1854-1861
Language
English
PMID
27796995
DOI
10.1007/s11356-016-7939-8
Web of Science Id
WOS:000394254000070
Abstract
Polychlorinated biphenyls (PCBs) have been recognized as metabolic disruptors. The liver plays a pivotal role in detoxification of an organism. Fatty liver results from altered intra-, and extra-hepatic mediators and is associated with increased glucose-related protein 78 (GRP78), commonly used as a marker for endoplasmic reticulum (ER) stress signaling. This pilot study aimed to study the effects of a single exposure on fatty liver metabolic parameters. The objective of the study is to characterize the effects of 3,3',4,4',5-pentachlorobiphenyl (PCB126) on ER stress protein chaperon GRP78 and CCAAT-enhancer-binding protein homologous protein (CHOP) and intra-hepatic mediators such as microsomal triglyceride transfer protein (MTP), sterol regulatory element-binding protein 1c (SREBP1c), and peroxisome proliferator-activated receptor alpha (PPARα), as well as extra-hepatic factors such as non-esterified fatty acid (NEFA) and tumor necrosis factor alpha (TNFα). Hepatic GRP78 mRNA and protein levels, indicating the presence of ER stress, were significantly increased following a single PCB126 exposure in rats. Intra-hepatic mechanisms such as lipoprotein secretion pathway (i.e., MTP), lipogenesis de novo (i.e., SREBP1c), and oxidation (i.e., PPARα) were altered in PCB126-treated rats. In addition, a state of inflammation measured by higher TNFα plasma levels was present in contaminated rats. These data indicate that a single injection of PCB126-modulated expression of GRP78 associated with hepatic ER stress and systemic inflammation in rats.
Keywords
Hepatic steatosis; Rats; Inflammation; Unfolded protein response; PCB126
Tags
IRIS
•
PCBs
Mechanistic
Supplemental
Litsearches
LitSearch: August 2016-August 2017
PubMed
Toxline
WoS
•
PCBs Tox Hazard ID
Administered mixture of < 4 individual PCB congeners
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