US EPA

4119545 

Journal Article 

Calcium and phosphate solubility in neonatal parenteral nutrient solutions containing TrophAmine 

Fitzgerald, KA; Mackay, MW 

1986 

Yes 

American Journal of Hospital Pharmacy
ISSN: 0002-9289 

IPA/86/672178 

J 

REF 9 

88-93 

English 

3082196 

IPA COPYRIGHT: ASHP Factors affecting solubilities of calcium and phosphate in neonatal total parenteral nutrient (TPN) solutions containing TrophAmine, a new amino acid formulation specific for pediatrics, were examined. Twelve TPN solutions were prepared in 10% dextrose injection. Some of the solutions also contained cysteine hydrochloride 40 mg/g protein and either sodium bicarbonate or hydrochloric acid (lipid emulsion buffer) to buffer the solution pH. Calcium gluconate and monobasic and dibasic potassium phosphate were added to 20-ml samples of the TPN solutions and achieved calcium concentrations of 10, 20, 30, 40, or 50 meq/l with phosphate concentrations of either 10, 20, 30, or 40 mmol/l. Samples were inspected visually and microscopically for precipitation or crystallization after 18 h at 25DG C and 37DG C, and solubility curves were prepared by plotting graphically. Temperature, amino acid concentration, and the addition of cysteine hydrochloride and lipid emulsion buffer each influenced the solubilities of calcium and phosphate in the TPN solutions. The use of TrophAmine allowed slightly greater concentrations of phosphate to be solubilized as compared with older amino acid formulations. It was concluded that the use of the solubility curves presented here should help pharmacists determine before preparation whether precipitation of monobasic and dibasic calcium phosphate may occur in TPN solutions containing TrophAmine.