Solubility of calcium and phosphate in two specialty amino acid solutions | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

4119603

Reference Type

Journal Article

Title

Solubility of calcium and phosphate in two specialty amino acid solutions

Author(s)

Mackay, MW; Fitzgerald, KA; Jackson, D

Year

1996

Is Peer Reviewed?

Yes

Journal

Journal of Parenteral and Enteral Nutrition
ISSN: 0148-6071

Report Number

IPA/97/1113334

Volume

Parenter

Issue

REF 17

Page Numbers

63-66

Language

English

PMID

8788265

DOI

10.1177/014860719602000163

Abstract

IPA COPYRIGHT: ASHP Determination of precipitation limits and construction of curves for calcium and phosphorus in parenteral nutrition solutions compounded with specialty amino acid solutions is described, and the effect of temperature, concentration of amino acids, and pH on the solubility of calcium gluconate (2.5-40 mEq/l) and potassium phosphate (2.5-40 mmol/l) in NephrAmine and HepatAmine is reported. Ten amino acid solutions were manufactured with NephrAmine and 12 with HepatAmine at amino acid concentrations of 0.8, 1.5, and 2%. The final dextrose concentration was 10%. Additives included cysteine hydrochloride, sodium bicarbonate, and hydrochloric acid. Relatively small changes in solution pH due to additional amino acids or due to the buffering of the solution to simulate the effects of lipids, caused dramatic changes in calcium and phosphate stability. Temperature and time also affected calcium and phosphate stability. Solubility curves plotted to represent calcium-phosphate solubility limits before visual or microscopic precipitation are given.