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HERO ID
4471224
Reference Type
Journal Article
Title
Physiologically based pharmacokinetic (PBPK) modeling of human lactational transfer of methylmercury in China
Author(s)
Ou, L; Wang, H; Chen, C; Chen, L; Zhang, W; Wang, X
Year
2018
Is Peer Reviewed?
1
Journal
Environment International
ISSN:
0160-4120
EISSN:
1873-6750
Publisher
Elsevier Ltd
Volume
115
Page Numbers
180-187
Language
English
PMID
29574338
DOI
10.1016/j.envint.2018.03.018
Web of Science Id
WOS:000432523500020
URL
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85044118332&doi=10.1016%2fj.envint.2018.03.018&partnerID=40&md5=e3e9ba36da7295d4695cd810259cbf97
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Abstract
Methylmercury can readily cross the human placental barrier and the blood-brain barrier and cause damage to the vulnerable developing brains of the fetus and infants. Most of the previous studies on the maternal transfer of methylmercury to the next generation have focused on the prenatal period. In this study, human physiologically based pharmacokinetic (PBPK) models of methylmercury were established for breastfeeding mothers and suckling infants based on the existing model prototypes of previous studies. Relevant parameters of the models were modified, and the validation was conducted based on measured data in North China. The models could effectively describe the human lactational transfer of methylmercury, including the time-dependent methylmercury levels in different tissues and organs of the breastfeeding mothers and suckling infants. The results indicated that 77.2% and 14.9% of methylmercury were excreted via hair and breast milk, respectively, from breastfeeding mothers during the first year after delivery. Meanwhile, 79.2% was excreted from the suckling infants during the first year after delivery via hair. Lactational transfer of methylmercury was considered an important pathway of methylmercury exposure for the breastfeeding infants, which accounted for approximately 80% of the accumulated adverse impacts at the early stages of human development.
Keywords
Methylmercury; Physiologically based pharmacokinetic (PBPK) modeling; Breastfeeding infant; Lactational transfer; Excretion
Tags
IRIS
•
Methylmercury
Literature Search: Mar 2017 - May 2019
Food Studies
Human Data
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ToxNet
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ADME Search: Jan 1990 - Nov 2018
PubMed
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Cited in Document
PBPK Search: Jan 2001-Oct 2019
Pubmed
Science Direct
WOS
Scopus
PBPK Text Review: October 2019
Included
NAAQS
•
ISA-PM (2019)
In Scope
Exposure
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