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4779370 
Book/Book Chapter 
Developmental and reproductive disorders: Role of endocrine disruptors in testicular toxicity 
Toor, JM; Sikka, SC 
2017 
Academic Press 
San Diego, CA 
Reproductive and developmental toxicology 
1111-1121 
English 
WOS:000463378100059 
has other version or edition 3444883 Developmental and reproductive disorders: Role of endocrine disruptors in testicular toxicity
is a chapter of 4779372 Reproductive and developmental toxicology (Second edition)
Several epidemiological studies suggest strong association of endocrine disruptors (EDs) with impaired male reproduction. High levels of polychlorinated biphenyls in serum are associated with low sperm count and poor fertility. A high dichloro diphenyl trichloroethane (DDT) concentration results in low serum testosterone (T) and poor semen quality. DDT stimulates estrogen production by acting as estrogen receptor agonist and potent androgen receptor antagonist. Phthalates, another group of EDs, induce seminiferous tubule degeneration with impaired spermatogenesis via disruption of gene expression that regulates cholesterol and lipid homeostasis resulting in low T. Bisphenol A, a strong exogenous estrogen with antiandrogen effect, lowers serum follicle-stimulating hormone, luteinizing hormone, and T, resulting in impaired development of seminiferous tubules and spermatogenesis. Di(2-ethylhexyl) phthalates can exert their antiandrogenic action by directly inhibiting testosterone biosynthesis via cytochrome P-450 dysfunction. Since these EDs are commonly found in plastic bottles, cosmetics, pesticides, some metal food cans, etc., and accumulate in the environment, it is very important to observe caution and avoid their exposure. 
Endocrine disruptors; Environmental toxicants; Male reproduction; Testicular toxicity; Testis development 
2nd 
Gupta, RC 
9780128042403 
• PFDA