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HERO ID
4934197
Reference Type
Journal Article
Title
Final report on the safety assessment of steareth-2,-4,-6,-7,-10,-11,-13,-15, and-20
Author(s)
Cosmetic Ingredient Review Expert Panel :: CIR Expert Panel
Year
1988
Is Peer Reviewed?
Yes
Journal
Journal of the American College of Toxicology
ISSN:
0730-0913
Volume
7
Issue
6
Page Numbers
881-910
Language
English
DOI
10.3109/10915818809078712
Web of Science Id
BCI:BCI198936058710
Abstract
The steareth group is a series of compounds prepared by reacting stearyl alcohol with ethylene oxide to form polyoxyethylene stearyl ethers. Steareths are waxy solids used primarily as emulsifiers in cosmetics at concentrations of up to 25%.
Steareth-2 and-10 were nontoxic to rats in acute oral toxicity studies. In subchronic testing, steareth-20 was nontoxic to rabbits when administered dermally at concentrations of 4%. Steareth-2 and-10, at concentrations of up to 60% in water, were at most mildly irritating to rabbit eyes and only mild irritants when tested in cosmetic formulations at concentrations of up to 60%.
Structurally similar polyoxyethylene alkyl ethers were neither mutagenic nor tumor promoters.
Steareth-2,-10, and-20 in water were neither primary irritants nor sensitizers to human skin. Steareth-20 was not phototoxic.
On the basis of the available data it is concluded that steareths-2,-4,-6,-7,-10,-11,-13,-15, and-20 are safe as cosmetic ingredients in the present practices of use and concentration.
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