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Citation
Tags
HERO ID
4946816
Reference Type
Journal Article
Title
Nonenzymatic determination of glucose at near neutral pH values based on the use of nafion and platinum black coated microneedle electrode array
Author(s)
Chinnadayyala, SR; Park, I; Cho, S
Year
2018
Is Peer Reviewed?
1
Journal
Microchimica Acta
ISSN:
0026-3672
EISSN:
1436-5073
Publisher
SPRINGER WIEN
Location
WIEN
Volume
185
Issue
5
Page Numbers
250
Language
English
PMID
29627889
DOI
10.1007/s00604-018-2770-1
Web of Science Id
WOS:000431462800002
Abstract
The authors report on a microneedle-based amperometric nonenzymatic glucose sensor for painless and continuous monitoring of glucose. It consists of 3 × 5 sharp stainless steel microneedles micromachined from a stainless steel substrate. The microneedles are 600 and 100 μm in height and width, respectively. Nafion and platinum black were sequentially coated onto the tip of gold-coated microneedles and used for nonenzymatic (direct) sensing of glucose. Attractive features of the modified microneedle electrode include (a) a low working potential (+0.12 V vs. Ag/AgCl), (b) a linear response in the physiologically relevant range (1-40 mM), (c) a sensitivity as high as 175 μA mM-1 cm-2, (d) a 23 μM detection limit, and (e) a response time of 2 s. The sensor also exhibits good reproducibility and stability. The sensor is selective for glucose even in the presence of 10-fold higher concentrations of ascorbic acid, lactic acid, dopamine, uric acid, and acetaminophen. Graphical abstract Schematic representation of the fabrication sequence for a nonenzymatic electrochemical glucose sensor using Nafion and platinum black coated microneedle electrode array. The sensor is based on measuring the faradaic current at +0.12 V vs. Ag/AgCl by the direct electrochemical oxidation of glucose to gluconic acid on the surface of a Pt black sensing layer.
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OPPT
•
Gluconates
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PubMed (private)
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Nafion
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