US EPA

498117 

Journal Article 

Review 

Cancer-related inflammation 

Mantovani, A; Allavena, P; Sica, A; Balkwill, F 

2008 

1 

Nature
ISSN: 0028-0836
EISSN: 1476-4687 

454 

7203 

436-444 

English 

18650914 

10.1038/nature07205 

WOS:000257860300038 

The mediators and cellular effectors of inflammation are important constituents of the local environment of tumours. In some types of cancer, inflammatory conditions are present before a malignant change occurs. Conversely, in other types of cancer, an oncogenic change induces an inflammatory microenvironment that promotes the development of tumours. Regardless of its origin, 'smouldering' inflammation in the tumour microenvironment has many tumour-promoting effects. It aids in the proliferation and survival of malignant cells, promotes angiogenesis and metastasis, subverts adaptive immune responses, and alters responses to hormones and chemotherapeutic agents. The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment. 

nf-kappa-b; necrosis-factor-alpha; tumor-associated macrophages; chemokine receptor cxcr4; colitis-associated cancer; cell lung-cancer; colorectal-cancer; ovarian-cancer; signaling pathway; bone-marrow