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HERO ID
5019113
Reference Type
Journal Article
Title
Biomarkers of toxicity in Clarias gariepinus exposed to sublethal concentrations of polycyclic aromatic hydrocarbons
Author(s)
Sogbanmu, TO; Osibona, AO; Oguntunde, OA; Otitoloju, AA
Year
2018
Is Peer Reviewed?
1
Journal
African Journal of Aquatic Science
ISSN:
1608-5914
EISSN:
1727-9364
Publisher
NISC Pty Ltd
Location
GRAHAMSTOWN
Volume
43
Issue
3
Page Numbers
281-292
Language
English
DOI
10.2989/16085914.2018.1491825
Web of Science Id
WOS:000445239000007
URL
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85052329551&doi=10.2989%2f16085914.2018.1491825&partnerID=40&md5=fa1e32bdd9aeb1ed6e59c67758d88558
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Abstract
Physiological, biochemical and histological indices in Clarias gariepinus broodstock, and teratogenic indices in embryos exposed to sublethal concentrations of naphthalene, phenanthrene and pyrene were investigated in 2014 using a static-renewal bioassay protocol. Phenanthrene (1.41 mg l(-1)) was the most toxic, followed by pyrene (1.53 mg l(-1)) and naphthalene (7.21 mg l(-1)), based on 96 h LC50 values. Hepatosomatic indices were significantly higher in naphthalene- and pyrene-treated males compared with solvent controls, whereas fecundity in females was significantly lower by factors of 2.4 (naphthalene), 2.8 (phenanthrene) and 2.4 (pyrene), compared with controls. Catalase levels were lower in female phenanthrene-treated fish compared with controls. Histological alterations observed in PAH-treated fish include oedema, inflammatory cells, epithelial lifting and hyperplasia in the gills, vacuolation, haemosiderin pigments and sinusoidal congestion in the liver, and degenerated zona radiata in the ovary. Teratogenic effects were not observed, as evidenced by the lack of histological alterations in embryos spawned from pre-exposed broodstock. Sex-specific responses and the utility of biomarkers at cellular and individual levels of organisation are therefore demonstrated for holistic evaluations of polycyclic aromatic hydrocarbons in ecotoxicological studies.
Keywords
African sharptooth catfish; biochemical indices; biological responses; histological alterations; naphthalene; phenanthrene; physiological indices; pyrene
Tags
IRIS
•
Naphthalene
Database Searches
WOS
Combined data set
Data set for title/abstract screening
Excluded - PECO criteria not met (TIAB)
Supplemental material
Mechanistic
Mechanisms of cancer
Feb 2019 Update
WOS
Other
•
Naphthalene (2021 Evidence mapping publication)
Database Searches
WOS
Combined data set
Data set for title/abstract screening
Excluded – PECO criteria not met
Supplemental material
Mechanistic
Mechanisms of cancer
Feb 2019 Update
WOS
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