US EPA

5043597 

Journal Article 

An aliphatic ester diisopropyl sebacate exhibited an adjuvant effect on fluorescein isothiocyanate-induced contact hypersensitivity mouse models 

Kurohane, K; Kimura, A; Terasawa, R; Kobayashi, K; Suzuki, W; Matsuoka, T; Imai, Y 

2018 

Yes 

Biological and Pharmaceutical Bulletin
ISSN: 0918-6158
EISSN: 1347-5215 

41 

1 

147-150 

English 

29081457 

10.1248/bpb.b17-00723 

Alternative plasticizers have become more popular due to health concerns about phthalate esters. We demonstrated that phthalate esters enhanced skin sensitization to fluorescein isothiocyanate (FITC) in mouse contact hypersensitivity models. Alternative plasticizers have not been well studied as to their effect on the immune system. We previously found that diisopropyl adipate (DIPA), an aliphatic dicarboxylic acid ester, enhanced skin sensitization to FITC. Sebacate esters are also widely used as alternative plasticizers. Here we tested diisopropyl sebacate (DIPS), which has the same alcohol with an aliphatic dicarboxylic acid of longer chain, using BALB/c mice. The results showed that DIPS facilitated skin sensitization to FITC and increased FITC-presenting dendritic cell trafficking from the skin to draining lymph nodes. Furthermore, DIPS activated transient receptor potential ankyrin 1 (TRPA1). The latter feature has been commonly observed for phthalate esters and DIPA, which have adjuvant effects. In summary, the adjuvant effect of a sebacate ester was demonstrated in a mouse model.