US EPA

5093044 

Journal Article 

Direct Esterification of Carboxylic Acids with Alcohols Catalyzed by Iron(III) Acetylacetonate Complex 

Weng, SS; Chen, FK; Ke, CS 

2013 

1 

Synthetic Communications
ISSN: 0039-7911 

43 

19 

2615-2621 

English 

10.1080/00397911.2012.725265 

WOS:000320914200007 

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84880160410&doi=10.1080%2f00397911.2012.725265&partnerID=40&md5=5f8a48be5ac718470e07d17386e4d8b5
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Direct condensation of carboxylic acids and alcohols with electronic, steric, and functional group variations was carried out using the environmentally benign, moisture-stable, inexpensive, and recoverable iron(III) acetylacetonate [Fe(acac)3] as catalyst (5 mol%). This iron salt efficiently catalyzed the esterification of several primary and secondary alcohols in refluxing xylene, without the need for a dehydration reagent. The chemoselectivity of the proposed protocol was demonstrated by the selective esterification of primary alcohol functionality in racemic 1-phenylethane-1,2- diol with benzoic acid. The esterification was also applicable to unmasked α-hydroxyacid, guasiaromatic, heterocyclic, and N-protected amino acids. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications® to view the free supplemental file. © 2013 Copyright Taylor and Francis Group, LLC. 

Esterification; iron(III) -diketonate species; recoverable catalyst