Ritter reaction of 1-aryl-1-fluoro-2-haloethanes | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

5094302

Reference Type

Journal Article

Title

Ritter reaction of 1-aryl-1-fluoro-2-haloethanes

Author(s)

Ho, TL; Chein, RJ

Year

2006

Is Peer Reviewed?

Yes

Journal

Journal of the Chinese Chemical Society
ISSN: 0009-4536

Volume

Issue

Page Numbers

429-430

Language

English

DOI

10.1002/jccs.200600054

Web of Science Id

WOS:000237261100024

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-34047153932&doi=10.1002%2fjccs.200600054&partnerID=40&md5=58ad874b7d3d405c5b0727a3f4a0f52f
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Abstract

Fluorinated phenethyl bromides 1,2, and 3, prove to be totally inert under Ritter reaction conditions in the presence of either SnCl4 or AgNO3, due to the strong deactivation by the gem-difluoro unit. Subjecting 2-bromo-1-fluoro-1-phenylethane to SnCl4 in MeCN at elevated temperatures led to formation of 2-methyl-4-phenyl-4,5-dihydrooxazole.

Keywords

Ritter reaction; 4,5-dihydrooxazole