Health & Environmental Research Online (HERO)


Print Feedback Export to File
5097907 
Journal Article 
Addendum to Iwai and Hoberman (2014)-Reassessment of developmental toxicity of PFHxA in mice 
Iwai, H; Hoberman, AM; Goodrum, PE; Mendelsohn, E; Anderson, JK 
2019 
Yes 
International Journal of Toxicology
ISSN: 1091-5818
EISSN: 1092-874X 
SAGE Publications Inc. 
38 
183-191 
English 
This article presents a supplemental data analysis and evaluation of the findings from an oral (gavage) combined developmental and perinatal/postnatal reproduction toxicity study of the ammonium salt of perfluorohexanoic acid (CASRN: 21615-47-4) in Crl: CD-1(ICR) mice. The original study has been cited as supporting a lowest-observed-adverse-effects level of 175 mg/kg/d and no-observed-adverse-effects level of 35 mg/kg/d for developmental effects from perfluorohexanoic acid (PFHxA, CASRN: 307-24-4) in mice. The statistical analysis reported in 2014 was accurate in terms of quantifying statistical significance within phase 2 of the study. However, given the low incidence of findings, the purpose of this article is to extend the analysis and interpretation of findings by pooling the control group information from both phases of the same study, comparing the study findings to the incidence rates for stillbirths and postpartum viability for this species and strain of mouse observed for similar studies conducted by the same laboratory, and evaluating data on the incidence and range of spontaneous eye abnormalities reported in the literature. Based on this supplemental evaluation, the original study supports a NOAEL of 175 mg/kg/d for PFHxA in mice, which is a factor of 5-fold higher than previously reported. Furthermore, to the extent that this study may be considered in the selection of a point of departure for PFHxA in mice, it is noted that 175 mg/kg/d for maternal exposure is an unbounded NOAEL for developmental effects, meaning that the study did not establish a dose at which developmental effects may occur. 
perfluorohexanoic acid; PFHxA; developmental toxicity 
PFAS
• Additional PFAS (formerly XAgency)
     Literature Search November 2019
          Other Sources
               TEDX
     Screened Studies
          Excluded
               Exclude (TIAB)
• Expanded PFAS SEM (formerly PFAS 430)
     Litsearch: September 2019
          Other Sources
               PFAS TOX Database
     Screened Studies
          Excluded
               Exclude (TIAB)
• PFAS 150
     Literature Search Update December 2020
          PubMed
          WOS
     Literature Search August 2019
          PubMed
          Web of Science
          Other sources
               PFAS TOX Database
     Not prioritized for screening
     Perfluorohexanoic acid
     1,1,1,3,3,3-Hexafluoro-2- (fluoromethoxy)propane
• PFAS Universe
     Data Source
          Web of Science
          Pubmed
          Screened Studies
               Excluded
                    Exclude (TIAB)
          Other sources
               ECHA
     Ammonium perfluorodecanesulfonate
     Ammonium perfluorohexanoate
     Perfluorohexanoate
     Perfluorohexanoic acid
• PFHxA
     LitSearch Update: Feb 2018 - May 2019
          PubMed
     Literature Search
          Pubmed
     LitSearch Update: May 2019 - May 2020
          WoS
     Scopus: April 2021
     Title and Abstract Screening
          Full Text Screening
          Tagged as Supplemental
     Results pulled from Pelch database May 2022
     HAWC