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Citation
Tags
HERO ID
5097907
Reference Type
Journal Article
Title
Addendum to Iwai and Hoberman (2014)-Reassessment of developmental toxicity of PFHxA in mice
Author(s)
Iwai, H; Hoberman, AM; Goodrum, PE; Mendelsohn, E; Anderson, JK
Year
2019
Is Peer Reviewed?
Yes
Journal
International Journal of Toxicology
ISSN:
1091-5818
EISSN:
1092-874X
Publisher
SAGE Publications Inc.
Volume
38
Issue
3
Page Numbers
183-191
Language
English
PMID
30983446
DOI
10.1177/1091581819837904
Web of Science Id
WOS:000473499100003
Abstract
This article presents a supplemental data analysis and evaluation of the findings from an oral (gavage) combined developmental and perinatal/postnatal reproduction toxicity study of the ammonium salt of perfluorohexanoic acid (CASRN: 21615-47-4) in Crl: CD-1(ICR) mice. The original study has been cited as supporting a lowest-observed-adverse-effects level of 175 mg/kg/d and no-observed-adverse-effects level of 35 mg/kg/d for developmental effects from perfluorohexanoic acid (PFHxA, CASRN: 307-24-4) in mice. The statistical analysis reported in 2014 was accurate in terms of quantifying statistical significance within phase 2 of the study. However, given the low incidence of findings, the purpose of this article is to extend the analysis and interpretation of findings by pooling the control group information from both phases of the same study, comparing the study findings to the incidence rates for stillbirths and postpartum viability for this species and strain of mouse observed for similar studies conducted by the same laboratory, and evaluating data on the incidence and range of spontaneous eye abnormalities reported in the literature. Based on this supplemental evaluation, the original study supports a NOAEL of 175 mg/kg/d for PFHxA in mice, which is a factor of 5-fold higher than previously reported. Furthermore, to the extent that this study may be considered in the selection of a point of departure for PFHxA in mice, it is noted that 175 mg/kg/d for maternal exposure is an unbounded NOAEL for developmental effects, meaning that the study did not establish a dose at which developmental effects may occur.
Keywords
perfluorohexanoic acid; PFHxA; developmental toxicity
Tags
PFAS
•
Additional PFAS (formerly XAgency)
Literature Search November 2019
Other Sources
TEDX
Screened Studies
Excluded
Exclude (TIAB)
•
Expanded PFAS SEM (formerly PFAS 430)
Litsearch: September 2019
Other Sources
PFAS TOX Database
Screened Studies
Excluded
Exclude (TIAB)
•
PFAS 150
Literature Search Update December 2020
PubMed
WOS
Literature Search August 2019
PubMed
Web of Science
Other sources
PFAS TOX Database
Not prioritized for screening
Perfluorohexanoic acid
1,1,1,3,3,3-Hexafluoro-2- (fluoromethoxy)propane
•
PFAS Universe
Data Source
Web of Science
Pubmed
Screened Studies
Excluded
Exclude (TIAB)
Other sources
ECHA
Ammonium perfluorodecanesulfonate
Ammonium perfluorohexanoate
Perfluorohexanoate
Perfluorohexanoic acid
•
PFHxA
LitSearch Update: Feb 2018 - May 2019
PubMed
Literature Search
Pubmed
LitSearch Update: May 2019 - May 2020
WoS
Scopus: April 2021
Title and Abstract Screening
Full Text Screening
Tagged as Supplemental
Results pulled from Pelch database May 2022
HAWC
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