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58201 
Journal Article 
Hepatotoxicity of inhaled trichloroethylene and tetrachloroethylene Long-term exposure 
Kylin, B; Sumegi, I; Yllner, S 
1965 
Yes 
Acta Pharmacologica et Toxicologica
ISSN: 0001-6683 
22 
4 
379-385 
Comparative investigations into the hepatotoxicity of, in particular the solvents trichloroethylene and tetrachloroethylene to mice after single exposures were reported in an earlier paper (KYLIN et al., 1963). The hepatotoxic effect was estimated by histological examination together with determination of extractable liver fat and of serum ornithine arbamoyl transferase (S-OCT). After 240 minutes exposure of the animals, trichloroethylene produced only slight fatty degeneration at a concentration as high as 3,200 ppm, whereas tetrachloroethylene caused moderate fatty degeneration at 200 ppm. With neither solvent was liver cell necrosis observed. In terms of fatty degeneration the hepatotoxic effects of tri- and tetrachloroethylene were approximately as 1 : 10.

The experimental study reported here was designed to elucidate the hepatotoxic effects of trichloroethylene and tetrachloroethylene over a period of weeks to mice receiving repeated exposure. 
IRIS
• Tetrachloroethylene (Perc) (Final, 2012)
     Hazard
          Liver
• Trichloroethylene (TCE) (Final, 2011)
OPPT REs
• OPPT_N-methylpyrrolidone (NMP)_F. Human Health
     Total – title/abstract screening
          On topic
               Peer review
                    Primary source
• OPPT_Perchloroethylene (Perc)_F. Human Health
     Total – title/abstract screening
          On topic
               Peer review
                    Primary source
               Cited in IRIS document or IRIS HERO page
     On topic - additional tags for titles/abstracts
          Animal hazard ID