US EPA

5882919 

Journal Article 

Review 

Implications of tryptophan photoproduct FICZ in oxidative stress and terminal differentiation of keratinocytes 

Furue, M; Uchi, H; Mitoma, C; Hashimoto-Hachiya, A; Tanaka, Y; Ito, T; Tsuji, G 

2019 

0 

Giornale Italiano di Dermatologia e Venereologia
ISSN: 0392-0488
EISSN: 1827-1820 

154 

1 

37-41 

English 

30035475 

10.23736/S0392-0488.18.06132-1 

WOS:000461732800007 

Ultraviolet B (UVB) irradiation activates aryl hydrocarbon receptor (AHR), generates reactive oxygen species (ROS) and mediates photocarcinogenesis and photoaging. 6-Formylindolo[3,2-b]carbazole (FICZ) is a tryptophan photoproduct generated by UVB exposure. FICZ exhibits similar biological effects to UVB, including AHR ligation and ROS production. FICZ also acts as a potent photosensitizer for UVA and the production of ROS is synergistically augmented in the simultaneous presence of FICZ and UVA. In contrast, FICZ upregulates the expression of terminal differentiation molecules such as filaggrin and loricrin via AHR. In parallel with this, the administration of FICZ inhibits skin inflammation in a murine psoriasis and dermatitis model. In this article, we summarize the harmful and beneficial aspects of FICZ in skin pathology.