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Citation
Tags
HERO ID
62160
Reference Type
Journal Article
Title
Arsenic and Raynaud's phenomenon: Vasospastic tendency and excretion of arsenic in smelter workers before and after the summer vacation
Author(s)
Lagerkvist, BEA; Linderholm, H; Nordberg, GF
Year
1988
Is Peer Reviewed?
Yes
Journal
International Archives of Occupational and Environmental Health
ISSN:
0340-0131
EISSN:
1432-1246
Volume
60
Issue
5
Page Numbers
361-364
Language
English
PMID
3384494
DOI
10.1007/BF00405671
Web of Science Id
WOS:A1988N382200008
URL
http://www.springerlink.com/index/10.1007/BF00405671
Exit
Abstract
Occupational and environmental exposure to inorganic arsenic is associated with the occurrence of Raynaud's phenomenon and objectively registered abnormal finger systolic blood pressure at local cooling (FSP). A subnormal FSP during cooling indicates a vasospastic tendency. It is not known whether these phenomena are related to recent or historical long-term exposure to arsenic. Twenty-one workers from a Swedish smelter were selected on the basis of exposure to arsenic dust for more than 14 years and a previously (three years earlier) recorded subnormal FSP during local cooling. The workers were examined before and after a 4 to 8 week summer vacation. After this intermission in arsenic exposure the urinary excretion of arsenic decreased to normal values, whereas the vasospastic reaction in the fingers remained. Thus the vasospastic tendency seems to be unrelated to the most recent urinary arsenic levels. FSP levels on cooling were significantly increased as compared with the measurements made three years earlier. This suggests a gradual improvement in finger blood circulation caused by decreased exposure to arsenic as evaluated over a time period of several years. The data thus indicate that peripheral vascular disturbances caused by arsenic are dependent on long-term arsenic exposures and are independent of short-term fluctuations in arsenic exposure.
Keywords
DCN-169072
;
Smelting
;
Arsenic poisoning
;
Cardiovascular system
;
Airborne dusts
;
Neurovascular disorders
;
Urinalysis
;
Blood pressure
Tags
IRIS
•
Arsenic (Inorganic)
1. Literature
PubMed
Toxline, TSCATS, & DART
Web of Science
3. Hazard ID Screening
Potentially relevant epidemiology studies
Cited in Volume 1
Cited in Volume 2a
Cited in Volume 2b
•
Arsenic Susceptibility
5. Health Effect
Cardiovascular disease
3. References Identified During Review
•
Inorganic Arsenic (7440-38-2) [Final 2025]
1. Initial Lit Search
PubMed
WOS
ToxNet
4. Considered through Oct 2015
8. Hazard through Oct 2015
Epi Hazard ID
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