US EPA

631194 

Journal Article 

Review 

Serial review: Role of reactive oxygen and nitrogen species (ROS/RNS) in lung injury and diseases 

Mossman, BT 

2003 

Yes 

Free Radical Biology and Medicine
ISSN: 0891-5849
EISSN: 1873-4596 

34 

9 

1130-1135 

10.1016/S0891-5849(03)00059-5 

WOS:000182315400003 

http://linkinghub.elsevier.com/retrieve/pii/S0891584903000595
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Chronic environmental and occupational exposures to low levels of metals arc associated with increased incidence ofpulmonary and cardiopulmonary diseases. The cellular and molecular mechanisms of action of metals in the lung are unresolved and involve complex pleiotrophic effects. These effects are mediated by direct reaction of the metals with cellular macromolecules and indirect effects of reactive oxygen species generated when cells are exposed to metals. This review focuses on cell signaling pathways activated by two metals, chromium and nickel, that are known to promote a variety of lung diseases, including fibrosis, obstructive disease, and cancer. These signaling pathways are discussed in relation to the inclusion or exclusion of reactive oxygen in mediating cellular activation following metal exposures. 

Chromium; Nickel; Fibrosis; Cell signaling; Free radicals