US EPA

6416398 

Journal Article 

Unexpected observations: Probiotic administration greatly aggravates the reproductive toxicity of perfluorobutanesulfonate in zebrafish 

Tang, L; Song, S; Hu, C; Lam, JC; Liu, M; Zhou, B; Lam, PKS; Chen, L 

2020 

Yes 

Chemical Research in Toxicology
ISSN: 0893-228X
EISSN: 1520-5010 

AMER CHEMICAL SOC 

WASHINGTON 

33 

7 

1605-1608 

English 

32372641 

10.1021/acs.chemrestox.0c00139 

WOS:000553242400011 

The present study exposed adult zebrafish to 0, 10 and 100 μg/L PFBS with or without dietary supplement of probiotic Lactobacillus rhamnosus. Interaction between probiotic and PFBS on sex endocrine and reproduction was investigated. It was striking to find that PFBS and probiotic coexposures almost ceased the fecundity, which was accompanied by disturbances in sex hormones and oocyte maturation in females. In contrast, probiotic additive efficiently antagonized the estrogenic activity of PFBS in males. For the first time, this study reported that probiotic heavily depended on sex to modulate the endocrine disruption and reproductive toxicity of aquatic pollutants. 

Animals; Dietary Supplements; Endocrine Disruptors; Estrogens; Female; Fluorocarbons; Gonadal Steroid Hormones; Lactobacillus rhamnosus; Male; Oocytes; Probiotics; Reproduction; Sulfonic Acids; Water Pollutants, Chemical; Zebrafish; 11 oxotestosterone; 3(or 17)beta hydroxysteroid dehydrogenase; aromatase; butane; cytochrome P450; endocrine disruptor; estradiol; estradiol 17beta dehydrogenase; gonadorelin; luteinizing hormone; luteinizing hormone receptor; perfluorobutanesulfonate; probiotic agent; testosterone; unclassified drug; estrogen; fluorocarbon; perfluorobutanesulfonic acid; sex hormone; sulfonic acid derivative; adult; animal experiment; animal model; animal tissue; Article; controlled study; dietary supplement; estrogen activity; female fertility; gonad; male fertility; nonhuman; oocyte maturation; reproductive success; reproductive toxicity; zebra fish; administration and dosage; animal; chemistry; drug effect; metabolism; oocyte; toxicity; water pollutant