US EPA

644243 

Journal Article 

Review 

Tobacco and pregnancy 

Rogers, JM 

2009 

1 

Reproductive Toxicology
ISSN: 0890-6238
EISSN: 1873-1708 

28 

2 

152-160 

English 

19450949 

10.1016/j.reprotox.2009.03.012 

WOS:000268849700004 

This paper will review the epidemiology of the impact of cigarette smoking and other forms of tobacco exposure on human development. Sources of exposure described include cigarettes and other forms of smoked tobacco, secondhand (environmental) tobacco smoke, several forms of smokeless tobacco, and nicotine from nicotine replacement therapy. Exposure is immense and worldwide, most of it due to smoking, but in some parts of the world and in some populations, smoking is exceeded by smokeless tobacco use. Nicotine and carbon monoxide exposure are of large concern, but cigarette smoke contains over 4000 chemical constituents and additives including known carcinogens, toxic heavy metals, and many chemicals untested for developmental toxicity. The impact of tobacco on human development will be reviewed. Fertility, conception, survival of the conceptus, most phases and aspects of development studied to date, as well as postnatal survival and health are adversely impacted by maternal tobacco use or exposure. Effects in surviving offspring are probably life-long, and are still being elucidated. It is hoped that this review will serve to keep a focus on the critical and continuing problem of tobacco use impacting human development. 

Abnormalities, Drug-Induced/epidemiology/*etiology/prevention & control; Adult; Female; Fertility/drug effects; Fetal Development/drug effects; Humans; Infant; Infant, Newborn; Maternal Exposure/*adverse effects; Meta-Analysis as Topic; Pregnancy; Pregnancy Complications/epidemiology/*etiology; Smoking/*adverse effects; Sudden Infant Death/epidemiology/etiology; Tobacco Smoke Pollution/*adverse effects/analysis; Young Adult