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Citation
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HERO ID
670877
Reference Type
Journal Article
Title
Mortality and end-stage renal disease incidence among dry cleaning workers
Author(s)
Calvert, GM; Ruder, AM; Petersen, MR
Year
2011
Is Peer Reviewed?
1
Journal
Occupational and Environmental Medicine
ISSN:
1351-0711
EISSN:
1470-7926
Volume
68
Issue
10
Page Numbers
709-716
Language
English
PMID
21172794
DOI
10.1136/oem.2010.060665
Web of Science Id
WOS:000294777000002
Abstract
Objective: Perchloroethylene (PCE) is a known animal carcinogen and probable human carcinogen. Dry cleaning exposures, particularly PCE, are also associated with renal toxicity. The objective was to follow-up a cohort of dry cleaners to evaluate mortality and assess end-stage renal disease (ESRD) morbidity.
Methods: This study adds 8 years of mortality follow-up for 1704 dry cleaning workers in four cities. Employees eligible for inclusion worked for ≥1 year before 1960 in a shop using PCE as the primary solvent. Life table analyses for mortality and ESRD morbidity were conducted. Only employees alive on 1 January 1977 were included in ESRD analyses.
Results: Overall cancer deaths were in significant excess in this cohort (standardised mortality ratio (SMR) 1.22, 95% CI 1.09 to 1.36). Oesophageal, lung and tongue cancers had significant excesses of deaths. Oesophageal cancer risk was highest among those employed in a PCE-using shop for ≥5 years with ≥20 years' latency since first such employment. Deaths from non-malignant underlying diseases of the stomach and duodenum were in significant excess. Hypertensive ESRD morbidity was significantly elevated in the entire cohort (standardised incidence ratio (SIR) 1.98, 95% CI 1.11 to 3.27), and among workers employed only in PCE-using dry cleaning shops for ≥5 years.
Conclusion: Employment in the dry cleaning industry and occupational exposure to PCE are associated with an increased risk for ESRD and for cancer at several sites. The employment duration findings for oesophageal cancer and hypertensive ESRD further support an association with PCE exposure instead of lifestyle or socioeconomic factors
EPub Date
12/16/2010
Publication Date
12/16/2010
Tags
•
Tetrachloroethylene (Perc) (Final, 2012)
Exposure
Hazard
Cancer Epi
Kidney
Liver
Immuno
Respiratory
Repro/Dev
Other Cancers
•
Trichloroethylene (TCE) (Final, 2011)
OPPT REs
•
OPPT_N-methylpyrrolidone (NMP)_F. Human Health
Total – title/abstract screening
On topic
Peer review
Primary source
•
OPPT_Perchloroethylene (Perc)_A. Summary
Cited in TSCA RE related document
•
OPPT_Perchloroethylene (Perc)_C. Engineering
Total – title/abstract screening
On topic
Peer review
Primary source
•
OPPT_Perchloroethylene (Perc)_D. Exposure
Total – title/abstract screening
Off topic
•
OPPT_Perchloroethylene (Perc)_E. Fate
Total – title/abstract screening
Off topic
•
OPPT_Perchloroethylene (Perc)_F. Human Health
Total – title/abstract screening
On topic
Peer review
Primary source
Cited in IRIS document or IRIS HERO page
On topic - additional tags for titles/abstracts
Human hazard ID
•
OPPT_Trichloroethylene (TCE)_C. Engineering
Total – title/abstract screening
Off topic
•
OPPT_Trichloroethylene (TCE)_D. Exposure
Total – title/abstract screening
Off topic
•
OPPT_Trichloroethylene (TCE)_E. Fate
Total – title/abstract screening
Off topic
•
OPPT_Trichloroethylene (TCE)_F. Human Health
Total – title/abstract screening
Off topic
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